WB;IF;IP;IHC

This antibody detects endogenous levels of HP1-gamma and does not cross-react with related proteins.

Purified recombinant human HP1-gamma protein fragments expressed in E.coli.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011],