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当前位置: 首页 > 产品中心 > 抗体 > 多克隆抗体 > SHIP-1 (phospho Tyr1021) Polyclonal Antibody
SHIP-1 (phospho Tyr1021) Polyclonal Antibody
  • 货号: YP-Ab-14371
  • 宿主: Polyclonal, Rabbit,IgG
  • 反应性: Human;Mouse;Rat
  • 应用: WB;IF;ELISA;IHC
SHIP-1 (phospho Tyr1021) Polyclonal Antibody
SHIP-1 (phospho Tyr1021) Polyclonal Antibody
订购:YP-Ab-14371
规格:
  • 53ul
  • 100ul
价格:
¥1340.00
数量:
- +
测试应用
WB;IF;ELISA;IHC
产品详情
Phospho-SHIP-1 (Y1021) Polyclonal Antibody detects endogenous levels of SHIP-1 protein only when phosphorylated at Y1021.
免疫原详细信息
The antiserum was produced against synthesized peptide derived from human SHIP1 around the phosphorylation site of Tyr1021. AA range:987-1036
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. A
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