产品详情
Phospho-IGF-IR (Y1161) Polyclonal Antibody detects endogenous levels of IGF-IR protein only when phosphorylated at Y1161.
免疫原详细信息
Synthesized phospho-peptide around the phosphorylation site of human IGF-IR (phospho Tyr1161)
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
