产品详情
This antibody detects endogenous levels of HER4 (Phospho Tyr1242) Rabbit pAb at Human, Mouse,Rat
免疫原详细信息
Synthesized peptide derived from human HER4 (Phospho Tyr1242)
相关试剂
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
背景
erb-b2 receptor tyrosine kinase 4(ERBB4) Homo sapiens This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],
