免疫原
Purified recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of TIF1 gamma / TRIM33 and does not cross-react with related proteins.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
其他名称
8030451N04Rik;AI413936;cb1085;DKFZp586K1123;E3 ubiquitin-protein ligase TRIM33;EC 6.3.2.-;Ectodermin;Ectodermin homolog;FLJ11429;FLJ32925;id:ibd2175;MGC136680;mKIAA1113; OTTHUMP00000013662;OTTHUMP00000013663;Protein Rfg7;PTC7;Ret fused gene 7;RET-fused gene 7 protein;RFG7;Rfg7 protein;TF1G;TIF1-gamma;TIF1G;TIF1GAMMA;TIFGAMMA;Transcription intermediary factor 1-gamma;Transcriptional intermediary factor 1 gamma;TRI33_HUMAN; Trim33;Tripartite motif containing 33;Tripartite motif containing 33 protein;tripartite motif-containing 33;Tripartite motif-containing protein 33;wu:fc17f10;zgc:136680.
背景
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],
功能
disease:A chromosomal aberration involving TRIM33 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.,function:Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to for
