免疫原
Purified recombinant human IL18 binding protein protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of IL18 binding protein and does not cross-react with related proteins.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
其他名称
I18BP_HUMAN;IL-18BP;IL18 BP;IL18 BPa;IL18BP;IL18BPa;Interleukin 18 binding protein; Interleukin-18-binding protein;MC51L 53L 54L homolog gene product;Tadekinig alfa; Tadekinig-alfa.
背景
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011],
功能
function:Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,tissue specificity:Strongly expressed in heart, lung, placenta and spleen.,
