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α-tubULin Monoclonal Antibody(8F11), AbFluor™ 405 Conjugated

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货号: YP-Ab-04689
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产品介绍

反应种属
Human;Rat;Mouse
应用范围
WB;IHC;IF;IP
抗体类型
内参抗体
基因名称(Gene Name)
TUBA1A
蛋白名称
TubULin alpha-1A chain
分子量（DA）
免疫原
特异性
α-tubULin Monoclonal Antibody(8F11) AbFluor™ 405 Conjugated specially designed for your Immunofluorescence analysis.
组成
Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
来源
Monoclonal, Mouse IgG
稀释比例
Optimal working dilutions shoULd be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300, IF 1:200.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度
1mg/ml
储存
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and th
其他名称
背景
MicrotubULes of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubULins. The genes encoding these microtubULe constituents belong to the tubULin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubULin families are found in all eukaryotes. The alpha and beta tubULins represent the major components of microtubULes, while gamma tubULin plays a critical role in the nucleation of microtubULe assembly. There are mULtiple alpha and beta tubULin genes, which are highly conserved among species. This gene encodes alpha tubULin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubULin genes in a cluster on chromosome 12q.
功能
disease:Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.,function:TubULin is the major constituent of microtubULes. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubULin tyrosine carboxypeptidase (TTCP) and tubULin tyrosine ligase (TTL), resp

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优品生物的抗体，可以回收利用几次？

首先，一般抗体不推荐客户回收利用，抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，优品生物也做过一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定。
注：我们将孵育完毕后剩余的抗体回收到离心管中置于4℃保存，效价高的抗体可至少保存1周，至少重复利用3次。

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优品生物作为国产抗体品牌的优势？

优品生物是国产品牌，通过聚焦抗体与酶核心技术，致力于打破国际技术的垄断，我们拥有包括兔多克隆抗体、小鼠单克隆抗体、兔单克隆抗体的生产研发平台，同时也有包括WB,IP在内的检测平台，我们对每一支自产的抗体进行了严格的检测。当然，我们部分直销地区也可以帮客户代购进口品牌的产品。同时也有抗体定制服务。优品生物l抗体优势：1，严自检，保质量；2产品多，指标全；3，价格低，货期短。

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优品生物抗体成分？

优品生物抗体成分在平时工作当中，常会有客户咨询我们的抗体用的什么buffer进行保存，一般来说，我们的buffer的成分是：PBS含0.03%的proclin300、0.05%牛血清白蛋白、50%甘油；也有一些是PBS含0.03%的proclin300，50%甘油。防腐剂 Proclin 300活性成分主要是2-甲基-4-异噻唑啉-3-酮（MCI）和5-氯-2-甲基-4-异噻唑啉-3-酮（CMCI）。ProClin生物灭活剂能够迅速穿透细胞膜，抑制对细胞呼吸至关重要的特定酶，因此一接触微生物有机体就会立即抑制细胞活性。ProClin的多个特定毒性位点可以防止微生物产生高水平的耐药性。

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