基因名称(Gene Name)
CTNND1 KIAA0384
蛋白名称
Cadherin associated Src substrate;Cadherin-associated Src substrate;CAS;Catenin (cadherin associated protein) delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;del
免疫原
Synthesized peptide derived from human p120 Catenin AA range: 600-700
特异性
The antibody can specifically recognize
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
来源
Mouse, Monoclonal/IgG2b, kappa
稀释比例
IHC 1:200-400. ELISA 1:500-5000
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
其他名称
Cadherin associated Src substrate;Cadherin-associated Src substrate;CAS;Catenin (cadherin associated protein) delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;delta 1 Catenin;KIAA0384;p120;P120 CAS;p120 catenin;P120 CTN;p120(cas);p120(ctn);P120CAS;P120CTN
背景
catenin delta 1(CTNND1) Homo sapiens This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010],
功能
alternative products:Experimental confirmation may be lacking for some isoforms,disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.,domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.,function:Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound clo
