反应种属
Human; Predict react with Mouse, Rat
基因名称(Gene Name)
PMEL D12S53E PMEL17 SILV
蛋白名称
95 kDa melanocyte specific secreted glycoprotein;95 kDa melanocyte-specific secreted glycoprotein;D12S53E;gp100;M-beta;ME20;ME20 M/ME20 S;ME20-M;ME20-S;ME20M;ME20M/ME20S;ME20S;Melanocyte lineage speci
免疫原
Synthesized peptide derived from human PMEL
特异性
The antibody can specifically recognize human PMEL protein.
组成
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
来源
Mouse, Monoclonal/IgG1, Kappa
稀释比例
IHC-p 1:200-400, WB 1:200-1000,
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
其他名称
95 kDa melanocyte specific secreted glycoprotein;95 kDa melanocyte-specific secreted glycoprotein;D12S53E;gp100;M-beta;ME20;ME20 M/ME20 S;ME20-M;ME20-S;ME20M;ME20M/ME20S;ME20S;Melanocyte lineage specific antigen GP100;Melanocyte protein mel 17;Melanocyte protein Pmel 17;Melanocyte protein Pmel 17 precursor;Melanocytes lineage-specific antigen GP100;Melanoma associated ME20 antigen;Melanoma gp100;Melanoma-associated ME20 antigen;Melanosomal matrix protein 17;Melanosomal matrix protein17;P1;p100;p26;PMEL 17;PMEL;PMEL_HUMAN;PMEL17;Premelanosome protein;Secreted melanoma-associated ME20 antigen;SI;SIL;SILV;Silver (mouse homolog) like;Silver homolog;Silver locus protein homolog;Silver, mouse, homolog of
背景
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011],
功能
function:Could be a melanogenic enzyme. Could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.,similarity:Belongs to the Pmel-17/NMB family.,similarity:Contains 1 PKD domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subcellular location:Probably product of proteolytic cleavage.,tissue specificity:Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas.,
