蛋白名称
Trans-acting T-cell-specific transcription factor GATA-3
免疫原
Purified recombinant fragment of human GATA-3 expressed in E. Coli.
特异性
GATA-3 Monoclonal Antibody detects endogenous levels of GATA-3 protein.
组成
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
纯化工艺
Affinity purification
其他名称
GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3
背景
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
功能
disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,
