蛋白名称
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
免疫原
Purified recombinant fragment of human BDH1 expressed in E. Coli.
特异性
BDH1 Monoclonal Antibody detects endogenous levels of BDH1 protein.
组成
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
纯化工艺
Affinity purification
其他名称
BDH1; BDH; D-beta-hydroxybutyrate dehydrogenase; mitochondrial; BDH; 3-hydroxybutyrate dehydrogenase
背景
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
功能
catalytic activity:(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.,enzyme regulation:Requires phosphatidylcholine as an allosteric activator for enzymatic activity.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Homotetramer.,
