免疫原
A synthetic phosphorylated peptide around S441 of mouse MLKL (NP_001297542.1)
纯化工艺
Affinity purification
储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
其他名称
9130019I15Rik; Phospho-MLKL-S441
背景
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein
kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a
critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death
process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling
molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential
for necroptosis. Alternatively spliced transcript variants have been found for this gene
