背景
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear
receptor superfamily and are key regulators of macrophage function, controlling
transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA
is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and
kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate
heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of
target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed
19436111]).
