免疫原
A synthetic peptide corresponding to a sequence within amino acids 691-770 of human β-
Amyloid(NP_000475.1)
纯化工艺
Affinity purification
储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
其他名称
AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP; β-
Amyloid(1-42)
背景
This gene encodes a cell surface receptor and transmembrane precursor protein that is
cleaved by secretases to form a number of peptides. Some of these peptides are secreted
and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional
activation, while others form the protein basis of the amyloid plaques found in the brains of
patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides,
having been shown to have bacteriocidal and antifungal activities. Mutations in this gene
have been implicated in autosomal dominant Alzheimer disease and cerebroarterial
amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several
different isoforms have been found for this gene.
