免疫原
Recombinant protein fo a sequence within amino acids 50-150 of human LEF1 (Q9UJU2).
纯化工艺
Affinity purification
储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
其他名称
LEF-1; TCF10; TCF7L3; TCF1ALPHA; LEF1
背景
This gene encodes a transcription factor belonging to a family of proteins that share
homology with the high mobility group protein-1. The protein encoded by this gene can bind
to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring
maximal enhancer activity. This transcription factor is involved in the Wnt signaling
pathway, and it may function in hair cell differentiation and follicle morphogenesis.
Mutations in this gene have been found in somatic sebaceous tumors. This gene has also
been linked to other cancers, including androgen-independent prostate cancer. Alternative
splicing results in multiple transcript variants.
