免疫原
A synthetic peptide corresponding to a sequence within amino acids 2200-2321 of human
NOTCH3 (NP_000426.2)
纯化工艺
Affinity purification
储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
其他名称
IMF2; LMNS; CASIL; CADASIL; CADASIL1; NOTCH3
背景
This gene encodes the third discovered human homologue of the Drosophilia melanogaster
type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands
(delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural
development. Homologues of the notch-ligands have also been identified in human, but
precise interactions between these ligands and the human notch homologues remains to be
determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
(CADASIL).
