免疫原
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human
Complement factor H (P08603).
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
其他名称
FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; Complement factor H
背景
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and
encodes a protein with twenty short consensus repeat (SCR) domains. This protein is
secreted into the bloodstream and has an essential role in the regulation of complement
activation, restricting this innate defense mechanism to microbial infections. Mutations in
this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic
hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized.
