免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of
human SPRTN (NP_001010984.1)
纯化工艺
Affinity purification
储存
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
其他名称
DVC1; PRO4323; spartan; C1orf124; SPRTN
背景
The protein encoded by this gene may play a role in DNA repair during replication of
damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA
replication forks where it may prevent excessive translesional DNA synthesis and limit the
number of DNA-damage induced mutations. It may also be involved in replication-related
G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal
instability and progeroid phenotypes. Mutations in this gene have been associated with
Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified
