背景
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-
mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine
degradation and cyanide detoxification. There is confusion in literature between this protein
(mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and
thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial
protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known
as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants
encoding same or different isoforms have been identified for this gene.
