产品详情
The antibody can specifically recognize human ZAP-70 protein.In western blotting of Jurkat cell lysate, the antibody can label a 70 kDa band corresponding to ZAP-70.
免疫原详细信息
Synthesized peptide derived from human ZAP-70
相关试剂
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
背景
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
