产品详情
The antibody can specifically recognize human MUC1 protein. In western blotting of NIH3T3 cell lysate, there shows a 122KDa band detected by the antibody.
免疫原详细信息
Synthesized peptide derived from human Epithelial Membrane Antigen(MUC1)
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.107% sodium azide.
背景
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate sp
