WB;IF;ELISA

Trk A Monoclonal Antibody detects endogenous levels of Trk A protein.

Purified recombinant extracellular fragment of human Trk A (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008],