产品详情
Bmi-1 Monoclonal Antibody detects endogenous levels of Bmi-1 protein.
免疫原详细信息
Purified recombinant fragment of human Bmi-1 expressed in E. Coli.
相关试剂
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
背景
BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],
