产品详情
Phospho-PKR (T451) Polyclonal Antibody detects endogenous levels of PKR protein only when phosphorylated at T451.
免疫原详细信息
The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr451. AA range:418-467
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
