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当前位置: 首页 > 产品中心 > 抗体 > 多克隆抗体 > Neu (phospho Tyr1221/Y1222) Polyclonal Antibody
Neu (phospho Tyr1221/Y1222) Polyclonal Antibody
  • 货号: YP-Ab-13047
  • 宿主: Polyclonal, Rabbit,IgG
  • 反应性: Human;Mouse;Rat;Monkey
  • 应用: WB;IHC;IF;ELISA
Neu (phospho Tyr1221/Y1222) Polyclonal Antibody
Neu (phospho Tyr1221/Y1222) Polyclonal Antibody
订购:YP-Ab-13047
规格:
  • 53ul
  • 100ul
价格:
¥1340.00
数量:
- +
测试应用
WB;IHC;IF;ELISA
产品详情
Phospho-Neu (Y1221/Y1222) Polyclonal Antibody detects endogenous levels of Neu protein only when phosphorylated at Y1221/Y1222.
免疫原详细信息
Synthesized phospho-peptide around the phosphorylation site of human Neu (phospho Tyr1221/Y1222)
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d
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