WB;ELISA

Phospho-Trk A (Y680/Y681) Polyclonal Antibody detects endogenous levels of Trk A protein only when phosphorylated at Y680/Y681.

The antiserum was produced against synthesized peptide derived from human Trk A around the phosphorylation site of Tyr680 and Tyr681. AA range:646-695

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008],