产品详情
APBB1 Polyclonal Antibody detects endogenous levels of protein.
免疫原详细信息
Synthesized peptide derived from human protein . at AA range: 400-480
相关试剂
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
背景
amyloid beta precursor protein binding family B member 1(APBB1) Homo sapiens The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012],
