产品详情
This antibody detects endogenous levels of FGFR3 (Phospho-Tyr724) at Human, Mouse,Rat
免疫原详细信息
Synthesized peptide derived from human FGFR3 (Phospho-Tyr724)
相关试剂
Liquid in PBS containing 50% glycerol, and 0.95% sodium azide.
背景
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dys
