产品详情
This antibody detects endogenous levels of Rad2/FEN1 (Phospho-Ser187) at Human, Mouse,Rat
免疫原详细信息
Synthesized peptide derived from human Rad2/FEN1 (Phospho-Ser187)
相关试剂
Liquid in PBS containing 50% glycerol, and 0.160% sodium azide.
背景
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions
