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当前位置: 首页 > 产品中心 > 抗体 > 多克隆抗体 > Shc (phospho-Tyr317) rabbit pAb
Shc (phospho-Tyr317) rabbit pAb
  • 货号: YP-Ab-03641
  • 宿主: Polyclonal, Rabbit,IgG
  • 反应性: Human;Mouse
  • 应用: WB;ELISA;IHC
Shc (phospho-Tyr317) rabbit pAb
Shc (phospho-Tyr317) rabbit pAb
订购:YP-Ab-03641
规格:
  • 53ul
  • 100ul
价格:
¥1340.00
数量:
- +
测试应用
WB;ELISA;IHC
产品详情
This antibody detects endogenous levels of Human Mouse Shc (phospho-Tyr317)
免疫原详细信息
Synthesized phosho peptide around human Shc (Tyr317)
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],
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