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当前位置: 首页 > 产品中心 > 抗体 > 多克隆抗体 > PHLDA3 Polyclonal Antibody
PHLDA3 Polyclonal Antibody
  • 货号: YP-Ab-04080
  • 宿主: Polyclonal, Rabbit,IgG
  • 反应性: Human;Mouse;Rat
  • 应用: WB;IHC;IF;ELISA
PHLDA3 Polyclonal Antibody
PHLDA3 Polyclonal Antibody
PHLDA3 Polyclonal Antibody
订购:YP-Ab-04080
规格:
  • 53ul
  • 100ul
价格:
¥1340.00
数量:
- +
测试应用
WB;IHC;IF;ELISA
产品详情
PHLDA3 Polyclonal Antibody detects endogenous levels of PHLDA3 protein.
免疫原详细信息
The antiserum was produced against synthesized peptide derived from human PHLDA3. AA range:21-70
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
domain:The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.,function:p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor.,induction:By p53/TP53; expression is directly activated by p53/TP53. p53/TP53 phosphorylation on 'Ser-15' is required to activate the PHLDA3 promoter.,miscellaneous:PHLDA3 genomic locus is frequently observed in primary lung cancers, suggesting a role in tumor suppression.,similarity:Belongs to the PHLDA3 family.,similarity:Contains 1 PH domain.,tissue specificity:Widely expressed with lowest expression in liver and spleen.,
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