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当前位置: 首页 > 产品中心 > 抗体 > 多克隆抗体 > MAML2 Polyclonal Antibody
MAML2 Polyclonal Antibody
  • 货号: YP-Ab-05710
  • 宿主: Polyclonal, Rabbit,IgG
  • 反应性: Human;Rat;Mouse;
  • 应用: WB;ELISA
MAML2 Polyclonal Antibody
MAML2 Polyclonal Antibody
订购:YP-Ab-05710
规格:
  • 53ul
  • 100ul
价格:
¥1340.00
数量:
- +
测试应用
WB;ELISA
产品详情
MAML2 Polyclonal Antibody detects endogenous levels of protein.
免疫原详细信息
Synthesized peptide derived from human protein . at AA range: 10-90
相关试剂
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
背景
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p
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