产品详情
This antibody detects endogenous levels of DSE at Human/Mouse
免疫原详细信息
Synthesized peptide derived from human DSE AA range: 164-214
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.249% sodium azide.
背景
The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016],
