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当前位置: 首页 > 产品中心 > 抗体 > 多克隆抗体 > MMP13 (Cleaved-Tyr104) rabbit pAb
MMP13 (Cleaved-Tyr104) rabbit pAb
  • 货号: YP-Ab-02311
  • 宿主: Polyclonal, Rabbit,IgG
  • 反应性: Human;Rat;Mouse;
  • 应用: WB;ELISA;IHC
MMP13 (Cleaved-Tyr104) rabbit pAb
MMP13 (Cleaved-Tyr104) rabbit pAb
订购:YP-Ab-02311
规格:
  • 53ul
  • 100ul
价格:
¥1340.00
数量:
- +
测试应用
WB;ELISA;IHC
产品详情
This antibody detects endogenous levels of Human MMP13 (Cleaved-Tyr104, protein was cleaved amino acid sequence between 103-104 )
免疫原详细信息
Synthesized peptide derived from human MMP13 (Cleaved-Tyr104)
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,disease:Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia type 2 (SEMD2) [MIM:602111]; also known as spondyloepimetaphyseal dysplasia type Missouri. SEMDs are a heterogeneous group of skeletal disorders characterized by defective growth and modeling of the spine and long bones. The SEMDs are distinguished from the spondylometaphyseal dysplasias and the spondyloepiphyseal dysplasias by the combined involvement of the epiphyses and metaphyses. The 3 disorders have malformations of the vertebrae in common.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Seems to be specific to breast carcinomas.,
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