产品详情
Phospho-Rb (S608) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S608.
免疫原详细信息
The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser608. AA range:581-630
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
